Jaguars will hold off Colts and protect AFC South lead

The Jaguars will defeat the Colts at EverBank Stadium on November 1, 2026. Jacksonville will protect its 4-2 lead in the AFC South and justify being a 7.5-point favorite while the Colts stay at 2-5 and face more division pressure. The Jaguars will win despite Anton Harrison being on injured reserve…